Publications
Bischof C, et al. Mitochondrial-Cell cycle crosstalk drives endoreplication in heart disease. Sci Translational Medicine, 2021, 13: 10.1126/scitranslmed.abi7964.
Lim GB. Metabolic dysregulation drives endoreplication in heart disease. Nat Rev Cardiol, 2021, 19: 10.1038/s41569-021-00666-6.
Mirtschink P, et al. Inhibition of the HIF1α-Induced Cardiospecific HERNA1 eRNA Protects from Heart Disease. Circulation, 2019. 139:2778-2792.
Mirtschink P, et al. HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. Nature, 2015. 522:444-449.
Maxeiner J, et al. Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs. J of Pharmacological and Toxicological Methods, 2021. 108: 106956-106964.
Krishnan J, et al. Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system. Genes Dev, 2012. 26:259-270.
Krishnan J, et al. Activation of a HIF1α-PPARγ axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab, 2009. 9:512-524.
Wagner JUG, et al. Novel SARS-CoV-2 variants induce higher toxicity in cardiovascular cells. European Heart Journal, 2021. 42: doi:10.1093/eurheartj/ehab724.3349.
Bojkova D, et al. SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes. Cardiovascular Research, 2020. 116: 2207–2215.
Trembinski et al. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Comm, 2020. 11: 2039-2045.
Wagner J, et al. Dissection of heterocellular cross-talk in vascularized cardiac tissue mimetics. J Mol Cell Cardiol, 2019. 138:269-282.
Rogg EM, et al. Analysis of cell type-specific effects of miR-92a provides novel insights into target regulation and mechanism of action. Circulation, 2018. 138:2545-2558.